Thomas Lobel, who now calls himself Tammy, is undergoing controversial hormone blocking treatment in Berkeley, California to stop him going through puberty as a boy.
But Pauline Moreno and Debra Lobel warn that children with gender identity disorder forced to postpone transitioning could face a higher risk of suicide.
Therapy: Thomas Lobel, who now calls himself Tammy, is undergoing controversial hormone blocking treatment
At age seven, after threatening genital mutilation on himself, psychiatrists diagnosed Thomas with gender identity disorder. By the age of eight, he began transitioning.
This summer, he started taking hormone-blocking drugs, which will stop him from experiencing puberty.
The couple faced intense criticism from friends and family as a result, Ms Moreno told MailOnline.
'Everybody was angry with us. "How could you be doing this? You might be ruining his whole life!"
Citing a statistic from the Youth Suicide Prevention Program, Ms Moreno noted over 50 per cent of transgender youth will have had at least one suicide attempt by their 20th birthday.
PROUD MOM: Two photos of Tammy from one of Pauline's Facebook albums called 'My Sweet Sweet Princess'
Here is Tammy with her mothers and older brother
Edgar at his recent bar mitzvah. Mother Pauline said Tammy was shy and
unhappy as a boy when compared to her older, outgoing brothers
Tammy favours headbands to baseball hats and picked out bras and dresses to start wearing when given choice in clothing to wear
'What is so frightening to me is that you would be willing to say "no" just because you don't like it - even though your child could lose their life?'
Her son's adolescent transition, she hopes, will help him have a less conflicted adulthood.
'The whole idea now is let's stop creating a third (gender) that is neither one thing or the other, so we transitioned her,' said Ms Moreno.
'The protocol now is to transition these children as soon as you can make a diagnosis, because otherwise they end up being not one thing or the other... because they experienced puberty.'
Ms Moreno recalled the first step of Thomas' transition to becoming female by letting him pick his own clothes.
He favoured headbands to baseball hats and picked out bras and dresses to start wearing when given choice in clothing to wear. And the change in his personality, Ms Moreno says, was instant.
'He was in his own world just completely detached and that was a problem we always had was getting Thomas to participate in life,' she said. 'What we saw emerge when Tammy was allowed to be Tammy is, "Whoa!"... It was an immediate transformation. She was so giggly and she was now interacting she was now making it a point to defend herself.'
The diagnosis has been hard to accept for Tammy's parents.
The couple were married in 1990 by a rabbi and have two older sons and grandchildren. But they insist their sexuality has nothing to do with it.
'It was odd to us,' she said. 'Even though she has lesbians as parents, this is all new to us in every possible way. We know what it's like to feel different - we've got that one. But to feel like you're not in the right body was just something we could not put our heads around.'
Fortunately, the family has a vast support system. The couple credits Tammy's teachers and officials at Children's Learning Center in Alameda, California, and their religious community, for being open-minded about their son's decision.
'We live in the Bay area where lots of alternative lifestyles are in place... and we belong to a religious community that was incredibly supportive. They make it a point when we're in synagogue to come over and tell Tammy, "Oh, you look so pretty today,' Ms Moreno said, adding, 'There's never going to be enough gratitude for them.'
His parents say the hormone treatment will give him time to figure out if he wants to fully transition to being female or go through puberty as a boy.
If he chooses to stop taking the drugs, he will undergo natural male puberty at a later stage and his future fertility would not be impacted.
Unhappy: Tammy was adopted aged two by Debra Lobel and Pauline Moreno
Pauline and Debra have been married since 1990, when they were joined in a commitment ceremony by their rabbi
San Francisco, right by Berkeley, is one of four cities in the United States with a hospital that has a program for transgender children.
The University of California San Francisco is home to the Center of Excellence for Transgender Health.
Children are seen at length by mental health professionals and then treated by pediatric endocrinologists.
Others cities with youth programs are Boston, Seattle and Los Angeles.
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